Isaac was born in 1968 in Barcelona. He studied architecture from 1986 in Barcelona before switching to fashion. In 1991, after finishing his degree, he started working for the Catalan fashion designer Antonio Miro for who he was in charge of the men's collection. In the late nineties, his curiosity and quest for quality took him to Paris. France seemed to be the best place to learn and get into the sophisticated savoir-faire in depth. Isaac started working for Hermès in 1998 in Paris, as the design assistant of Véronique Nichanian for the men's collection. Isaac created his own eponymous accessories brand in 2006. The first Isaac Reina store was opened in a row in 2006 and is still located in the Marais area, 12 rue de Thorigny.